Plasma extracellular vesicle signatures of metabolic health and exercise response in a pilot study of older adults

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Extracellular vesicles (EVs) are key mediators of intercellular communication and regulators of cellular function, yet their roles in metabolic health and exercise response are poorly understood. This pilot study analyzed plasma from older adults ( n = 20) in subgroups of the well-characterized Studies Targeting Risk Reduction Interventions through Defined Exercise (STRRIDE) study to evaluate plasma EV biomarkers as minimally invasive biomarkers of metabolic health and exercise responsiveness. Plasma EVs comprised highly heterogeneous subpopulations defined by diverse surface markers reflecting complex cellular origins. At baseline, multiple EV biomarkers related to immune cells, skeletal muscle, and mesenchymal stem cells were associated with better indices of insulin action, including nine EV subpopulations with lower fasting insulin concentration and eight with lower Homeostatic Model Assessment for Insulin Resistance. Low-amount (∼1,300 kcal/wk), vigorous-intensity (65%-80% peak oxygen consumption) aerobic exercise increased the FABP4 + EV subpopulation in older adults ( n = 12). High-amount (∼2,200 kcal/wk), vigorous-intensity exercise increased 15 EV subpopulations in older adults ( n = 8). These subpopulations arise from a variety of cell sources, including immune cells (primarily lymphoid cells), skeletal and cardiac muscle, erythroid cells, mesenchymal and hematopoieti

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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