Plasma proteomics of extracellular vesicles identifies key proteins correlating to postoperative atrial fibrillation after coronary artery bypass surgery
Chen HX., Yang Q., He GW.
Prospective Study with a reported sample of 6, published in Clin Proteomics (2026) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Clin Proteomics (2026)
- Reported sample size
- 6
- Source database
- Europe PMC
- PMID
- 42032453
- PMCID
- PMC13274030
- DOI
- 10.1186/s12014-026-09606-3
Abstract (original English)
BACKGROUND: New-onset postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) is a major complication and the precise mechanism remains unclear. EVs have become a special intercellular information transmission system secreted from different cells. The present study aimed to identify differentially expressed proteins (DEPs) of the plasma exosomes (Extracellular Vesicles, EVs) from patients with POAF after CABG and explored the pathogenesis of POAF. METHODS: Label-free quantitative LC–MS/MS proteomics analyses were performed to find changes in protein levels proteomic alterations in plasma EVs of patients with POAF (n = 6) after CABG and sinus rhythm (SR, n = 6). The DEPs screened by bioinformatics analysis were validated by parallel reaction monitoring (PRM) quantitative analysis from a new set of plasma samples (POAF n = 9; SR n = 9). RESULTS: Exosomal proteomics identified 51 significant DEPs including 29 up-regulated and 22 down-regulated proteins in POAF group compared to the SR control. Bioinformatics analysis showed that the DEPs were significantly enriched in cysteine and methionine metabolism, Toll-like receptor signaling pathway, AGE-RAGE signaling pathway in diabetic complications and Diabetic cardiomyopathy. The PRM reconfirmed that serum amyloid P-component and Collagen alpha-2(I) chain were significantly down-regulated in POAF group. CO
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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