Platelet-rich plasma and other injectables in the young athlete
Syed AN., Landrum K., Ganley TJ.
Narrative Review, published in J Pediatr Soc North Am (2024) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- J Pediatr Soc North Am (2024)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40433253
- PMCID
- PMC12088118
- DOI
- 10.1016/j.jposna.2024.100008
- Citations
- 1
Abstract (original English)
Pediatric sports participation and subsequent injuries have increased in parallel. Additionally, pediatric athletes and families are highly invested in rapid return to pre-injury status and the ability to sustain high impact loads and tension. Recently, an increase and diversification of biologically derived substances, known as orthobiologics, have been used to accelerate tissue healing. While commonly used in adults, the indications are ambiguous, and evidence for effectiveness is conflicting. Despite this, an interest in pediatric indications for orthobiologics has increased as both a standalone intervention and as a supplement to current treatment. There is a dearth of literature pertaining to the pediatric population, which warrants a review of what research has been performed. The purpose of this review was to critically examine the indications and results of orthobiologics in immature athletes. Much of the existing literature is composed of case studies or studies performed with relatively small sample sizes. As such, we believe more research is needed in almost every context for absolute guidelines and recommendations to be established. While orthobiologics have been purported to provide a significant healing benefit to augment the treatment of sports injuries, we find no additional benefit compared to standard treatment. Key concepts 1)While orthobiologics have been us
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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