Platelet-rich plasma versus plasma gel for fat graft survival under cigarette smoke exposure: An experimental study.
Naghizade B., Özyazgan İ., Bozkurt F., Turan IT., Ülger M., Gönen ZB.
Animal Study with a reported sample of 10, published in J Plast Reconstr Aesthet Surg (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- J Plast Reconstr Aesthet Surg (2026)
- Country
- Netherlands
- Reported sample size
- 10
- Source database
- PubMed
- PMID
- 42241808
- DOI
- 10.1016/j.bjps.2026.05.060
Abstract (original English)
Background Autologous fat grafting is widely used in plastic surgery, but graft survival remains unpredictable, particularly under compromised conditions such as cigarette smoking. Smoking impairs microcirculation and tissue oxygenation, adversely affecting graft viability. Platelet-rich plasma (PRP) has been proposed as a biological adjunct that enhances angiogenesis and tissue regeneration. Plasma gel (PG), similarly derived from PRP and retaining various growth factors, as a fibrin-based volumizing scaffold. This study aimed to evaluate whether PRP or PG can mitigate cigarette smoke-induced impairment of fat graft survival and to compare their respective effects. Methods Thirty male Sprague-Dawley rats were assigned to control (n = 10) and smoke-exposed groups (n = 20). Smoke-exposed animals were divided into PRP (n = 10) and PG (n = 10) groups. After six weeks of smoke exposure, autologous fat grafts were implanted bilaterally, with the right side receiving treatment and the left side serving as an internal control. After six weeks, graft retention and histological parameters were evaluated. Results Smoke exposure reduced graft retention and increased fibrosis and necrosis. PRP improved graft retention (64.9% vs 36.5%, p = 0.004), reduced necrosis, and increased viable adipose tissue. PG did not improve graft retention (p = 0.084) and was associated with higher fibrosis (p
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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