Platelets facilitate fat grafting by mitochondrial transfer and reducing oxidative stress in adipose-derived stem cells.
Ke C., Liu K., Chen W., Cai Z., Yang F., Wei Q.
Animal Study, published in Stem Cells Transl Med (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Stem Cells Transl Med (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41235767
- PMCID
- PMC12616471
- DOI
- 10.1093/stcltm/szaf059
- Citations
- 1
Abstract (original English)
Autologous fat grafting (AFG), characterized by a broad tissue source and absence of immune rejection, is extensively utilized in plastic surgery. Despite its advantages, AFG is frequently challenged by a high rate of fat resorption and limited volume retention. Recent studies have increasingly focused on integrating platelet-related preparations with adipose tissue to enhance graft survival rates. These investigations have consistently demonstrated the beneficial effects of platelets and their derivatives on adipose-derived stem cells (ADSCs), facilitating improved outcomes in fat transplantation. Nevertheless, the precise mechanisms governing the interaction between platelets and ADSCs remain insufficiently understood. We investigate the potential of platelets to augment the antioxidant stress capacity of ADSCs through mitochondrial transfer, thereby contributing to enhanced fat graft viability. Experimental results revealed that platelets significantly promoted ADSC proliferation, migration, metabolic activity, and mitochondrial function. Co-culture of oxidative stress-induced ADSCs with platelets resulted in improved cell viability and a marked reduction in reactive oxygen species (ROS) levels. The mitochondrial transfer from platelets to ADSCs, confirmed via fluorescent labeling, played a pivotal role in restoring mitochondrial function and decreasing glucose consumption u
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
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