Polylactic Acid/Polyvinylpyrrolidone Scaffolds With Adipose Tissue-Derived Mesenchymal Stem Cells Enhance Nerve Regeneration in Rats.
Javadov T., Unal S., Katmis A., Sakar M., Akakin D., Demirci EK.
Animal Study, published in ASAIO J (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- ASAIO J (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40407069
- DOI
- 10.1097/MAT.0000000000002463
Abstract (original English)
The aim of this study was to investigate the treatment effect of an artificial nerve graft produced with polylactic acid (PLA) and polyvinylpyrrolidone (PVP) by electrospinning method, in combination with rat allogeneic adipose tissue-derived mesenchymal stem cells (rAT-MSCs), on axonal regeneration in a rat sciatic nerve injury. A 10 mm long gap in the right sciatic nerve was created in rats which were divided into three groups and the gap was repaired with autologous nerve graft (autograft group), PLA/PVP conduit alone (PLA/PVP group), and PLA/PVP conduit with rAT-MSCs inside (PLA/PVP with rAT-MSC group). At the end of the eighth week, the results were evaluated functionally, electrophysiologically, and histologically. In functional evaluation, sciatic functional index (SFI) was used and all groups showed improvement over time. The results were seen in the autograft and PLA/PVP with rAT-MSC groups, with no statistically significant difference between them. In electrophysiological evaluation, action potential was seen in all three groups, with the best results seen in the PLA/PVP with rAT-MSC group with statistical significance. Histological evaluation showed axonal regeneration in all three groups. These results show that PLA/PVP conduit contributes to regeneration even when used alone, and increases regeneration when used together with rAT-MSCs.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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