Preadipocyte Uncoupling Protein 1 Expression Invoked by Fibroblast Growth Factors Imprints on Post-Differentiation White and Brown Adipocyte Phenotype

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Uncoupling protein 1 (UCP1) is a hallmark of thermogenic adipocytes and enables heat production by dissipating energy from mitochondrial proton motive force as heat. The purpose of its recently discovered presence in preadipocytes in response to certain fibroblast growth factors (FGFs) remains elusive. In this study, we systematically investigated the potential of all paracrine FGFs to invoke UCP1 expression in murine preadipocytes derived from interscapular brown and inguinal white adipose tissue. FGF2, FGF4, FGF8, and FGF9 induced UCP1 expression in undifferentiated preadipocytes, with FGF2 acting most potently and rapidly. This premature UCP1 induction did not translate into increased UCP1 thermogenic activity after complete adipogenic differentiation. Notably, preadipocyte treatment with FGFs and parallel UCP1 expression led to a sustained suppression of interferon-stimulated genes after differentiation. Preadipocyte UCP1 was required and sufficient for this lasting imprint. Thus, FGF-induced UCP1 expression in preadipocytes programs a lasting post-differentiation anti-inflammatory status.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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