Preliminary Report on the Time-Related Effect of a Single Autologous Adipose-Derived Mesenchymal Stem Cells Injection in Hip Osteoarthritis: A Retrospective Observational Study.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background: Recently, intra-articular injection of mesenchymal stem cells (MSCs) had been proposed as a conservative treatment for hip osteoarthritis (HOA). Adipose tissue was demonstrated as a viable source of MSCs because of the high concentration of cells and the easy access to the donor site. The purpose of this study was to evaluate the time-related results of a single intra-articular injection of autologous adipose-derived stem cells (aASCs) in a series of patients with HOA. Methods: A retrospective study was conducted on 30 patients with HOA, who underwent an intra-articular injection of aASCs between September 2018 and January 2021. Inclusion criteria for the procedure were as follows: onset of symptoms of the affected hip in the prior six or more months ago, failure of the conservative treatment (NSAIDs and/or physiotherapy) and age > 18 years. Exclusion criteria were trauma in the affected hip occurred in the previous 3 months, recent arthroscopic treatment, infectious joint disease, chondromatosis of the hip or any other secondary HOA, malignancy, hyaluronic acid or other injections in the previous 6 months and incomplete follow-up. Because a low BMI makes extremely difficult to harvest enough adipose tissue, patients with a BMI < 18 were also excluded. The Oxford Hip Score, the 12-item Short Form Survey and Visual Analogue Scale were used to evaluate the results of

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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