Level C· Early human research exploring benefitsProspective StudyEurope PMCOpen access

Preservation Arthroplasty for Basal Joint Arthritis Using Arthroscopy and Autologous Fat Grafting With Platelet-rich Plasma

Deptula P., McCullough M., Brown T., Singh D., Tanabe K., Tsai E.

Prospective Study on Osteoarthritis, published in Plast Reconstr Surg Glob Open (2025) — summary generated from the PubMed abstract.

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Level C· Early human research exploring benefitsEvidence level of this study

Early human evidence such as case series or small samples is exploring possible benefits.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
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This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Prospective Study
Journal
Plast Reconstr Surg Glob Open (2025)
Reported sample size
—
Source database
Europe PMC
PMID
40275905
PMCID
PMC12020691
DOI
10.1097/gox.0000000000006720

Abstract (original English)

Background Prior studies have shown that intra-articular injection of autologous fat may be a viable, less invasive approach for the treatment of carpometacarpal (CMC) joint arthritis, compared with trapeziecetomy. Small joint arthroscopy has also been found to be a useful tool in evaluation and treatment of arthritis. The authors present a treatment for CMC arthritis combining a minimally invasive approach for arthroscopic debridement with autologous fat grafting and platelet-rich plasma (PRP) injection. Methods Patients with Eaton stage II-IV CMC osteoarthritis underwent arthroscopic debridement and injection of autologous fat and PRP into the joint. Pre- and postoperative pain scores, functional outcomes, radiographic improvement in joint subluxation, patient satisfaction, and complications were evaluated. Results Forty-eight thumb CMC joint arthroscopies with fat grafting and PRP were performed. No intraoperative or immediate postoperative complications were experienced. No patients required revision surgery. Average preoperative pain scores with activity improved from 8.9 ± 0.9 to 3.3 ± 2.2 ( P P 1 M 2 overlap was used to measure radiographic subsidence. This improved from 4.4 ± 2.8 mm preoperatively to 6.8 ± 2.3 mm postoperatively, reflecting a relative improvement of 70% ( P Conclusions Treatment of the CMC joint using arthroscopic technique combined with autologous fat

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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