Production of the Key Immunoregulatory Cytokines and the Content of FoxP3 + T-Regulatory Lymphocytes in the Epicardial and Thymus Adipose Tissue in Patients with Coronary Heart Disease.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

FoxP3 + T-regulatory (Treg) lymphocytes and cytokine production by cells from the stromal vascular fraction (SVF) of epicardial (EAT) and thymus (TAT) adipose tissue of 42 patients with chronic coronary heart disease (CHD) were studied. In the SVF of TAT in patients with Gensini Score (GS)≥74 (the most severe atherosclerosis), the production of IL-1β, TNF, IL-4, and IFNγ was higher, while FoxP3 translocation into the nucleus was lower than in patients with GS<74. The GS index directly correlated with the production of IL-4, IL-1β, and TNF by cells of the SVF of TAT, and inversely - with the production of TNF, IL-17, and IL-10 by cells of the SVF of EAT. The proportion of CD25 hi FoxP3 + Treg with FoxP3 nuclear translocation in TAT inversely correlated with IFNγ production in TAT and directly correlated with IL-4 production in EAT. The results obtained suggest that the severity of coronary atherosclerosis is interrelated with the ability of SVF cells of EAT and TAT to produce cytokines and the properties of FoxP3 + Treg lymphocytes.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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