Programmable DNA-based biomaterials for bone tissue engineering
Xu X., Kou E., Zhang H., Zhang K., Zhang H.
Narrative Review, published in Fundam Res (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Fundam Res (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40777770
- PMCID
- PMC12327870
- DOI
- 10.1016/j.fmre.2024.12.015
- Citations
- 1
Abstract (original English)
Bone defects are a common pathology in bone tissue diseases, and existing therapeutic interventions have significant limitations, highlighting the need for innovative strategies and advanced biomaterials. DNA, traditionally recognized as a prominent genetic material, also possesses exceptional properties as a biological material, making it an ideal nanoscale building block for creating various DNA-based biomaterials, such as DNA framework materials and DNA hydrogels. DNA-based biomaterials offer notable advantages, including structural versatility, biocompatibility, and, crucially, programmability, which position them as promising candidates for bone tissue engineering. This review explores recent advancements in the use of DNA-based biomaterials for bionic mineralization and drug delivery systems, as well as their future potential in this field.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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