Progress in the Application of Multifunctional Composite Hydrogels in Promoting Tissue Repair
Hui Y., Zheng X., Zheng Z., Wu C., Hao Y., Zhou B.
Narrative Review, published in ACS Omega (2024) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- ACS Omega (2024)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 39676986
- PMCID
- PMC11635483
- DOI
- 10.1021/acsomega.4c08103
- Citations
- 5
Abstract (original English)
Tissue repair is an extremely complex process, and effectively promoting tissue regeneration remains a significant clinical challenge. Hydrogel materials, which exhibit physical properties closely resembling those of living tissues, including high water content, oxygen permeability, and softness, have the potential to revolutionize the field of tissue repair. However, the presence of various complex conditions, such as infection, ischemia, and hypoxia in tissue defects, means that hydrogels with simple structures and functions are often insufficient to meet the diverse needs of tissue repair. Researchers have focused on integrating multiple drugs, nanomaterials, bioactive substances, and stem cells into hydrogel matrices to develop novel multifunctional composite hydrogels for addressing these challenges, which have superior antibacterial properties, hemostatic abilities, self-healing capacities, and excellent mechanical properties. These composite hydrogels are designed to enhance tissue repair and have become an important direction in the current research. This review provides a comprehensive review of the recent advances in the application of multifunctional composite hydrogels in promoting tissue repair, including drug-loaded hydrogels, nanomaterial composite hydrogels, bioactive substance composite hydrogels, and stem cell composite hydrogels.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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