Progress and future prospects for the surgical treatment of permanent hypoparathyroidism after thyroid surgery: a narrative review
Zhang D., Guo L., Wu J., Ning N., Chen L.
Narrative Review, published in BMC Surg (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- BMC Surg (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41413516
- PMCID
- PMC12825182
- DOI
- 10.1186/s12893-025-03413-7
Abstract (original English)
Background and objective The most prevalent complication following total thyroidectomy is hypoparathyroidism. Permanent hypoparathyroidism poses a significant medical burden, necessitating lifelong medication and regular follow-up. Parathyroid transplantation has demonstrated its biological efficacy and is therefore widely utilized in total thyroidectomy procedures. However, the mechanisms and treatment approaches vary considerably, lacking standardized guidelines. Methods We conducted a narrative review of relevant literature on PubMed using the keywords "Parathyroid gland, transplantation, autotransplantation, allotransplantation, hypoparathyroidism, total thyroidectomy" to elucidate the surgical management and future prospects for permanent postoperative hypoparathyroidism (PPH). Key content and findings Preservation of the parathyroid gland blood supply and prevention of inadvertent parathyroid removal during thyroid surgery, performed by a skilled surgeon, are crucial for preventing PPH. Parathyroid autotransplantation (PAT) during thyroidectomy significantly reduces the occurrence of PPH. For established PPH, alternative techniques include transplantation of autologous cryopreserved parathyroid tissue (PT) and parathyroid allotransplantation. Conclusions Current management of PPH primarily encompass high-dose vitamin D and calcium supplementation, parathyroid hormone (PTH
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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