Proliferation of human adipose tissue-derived stem cells stimulated by oil rich in thymol of Lippia origanoides.
Brito FN., Vendramin FS., Lopes CTA., Costa MPR., Ohashi OM., Maia JGS.
Laboratory Study, published in Acta Cir Bras (2018) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Acta Cir Bras (2018)
- Country
- Brazil
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 29924207
- DOI
- 10.1590/s0102-865020180050000005
- Citations
- 4
Abstract (original English)
Purpose To evaluate the effects of this thymol-rich oil in the proliferation of human adipose tissue-derived stem cells. Methods Stem cells were isolated from human adipose tissue by liposuction. After the first passage, cells were cultivated in triplicate for three days in control medium and medium supplemented with three oil samples (1.0 μg/mL, 5.0 μg/mL, and 25.0 μg/mL). Cells were analyzed by the MTT assay at passage 1 (P1), and cell proliferation of control and 1 μg/mL groups was determined with a hemocytometer at P2 and P3. Results Viability of the essential oil-treated cells was significantly higher than the control group at P1 (p = 0.0008). The treatment with the oil, at a concentration of 1 µg/mL, led to increases of 24.8% at P1 and 43.0% at P3 in the rate of cell proliferation compared with control cells. Conclusion Supplementing culture medium with essential oil of Lippia origanoides increased cell proliferation, especially at later passages.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.