Properties and origin of osteoblasts.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Osteoblastic and chondroblastic (i.e., osteogenic) cells belong to the stromal cell system, which is associated with bone marrow, and bone and is separate from the hematopoietic stem-cell system. Stromal stem cells are capable of producing reticular, fibroblastic, osteogenic, and adipose stromal lines. Marrow-derived osteogenic cells are a component of marrow stroma, which in vitro form fibroblastic-type colonies. These colonies are a heterogeneous population with varying enzymatic expressions and potencies that differentiate into fibroblastic, reticular, adipocytic, and osteogenic populations. It is postulated that these colonies are a component of the stem- and progenitor cell populations. Progenitors of osteogenic cells are widely distributed in the extraskeletal organs. On contact with an adequate inductor, they differentiate into chondro- and/or osteoblasts, thus producing ectopic (i.e., induced) cartilage and/or bone. Such osteoprogenitor cells were termed inducible osteoprogenitor cells, in contrast to the determined osteoprogenitor cells, which are present in the bone marrow stroma and produce bone spontaneously. To the class of determined osteoprogenitors also belong endosteal cells, periosteal cells, and osteoblastic established cell lines. There is no evidence of the presence of osteogenic cells in the blood and peritoneal fluid. The concept of mesenchymal cells as a

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.