A prospective single-arm study on the effects of repeated intravenous infusions of canine adipose-derived mesenchymal stromal cells in dogs with chronic inflammatory enteropathy.

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Mesenchymal stromal cells (MSCs) are a promising cell source for the treatment of dogs with refractory chronic inflammatory enteropathy (CIE). Although several clinical trials have reported the beneficial effects of MSCs for CIE, all previous studies were conducted by the same research group using a single intravenous infusion protocol. Because most intravenously infused MSCs rapidly disappear from the body, repeated infusions of these cells at regular intervals may prolong the short-term effects of MSCs. This study evaluated the short-term clinical outcomes and safety of a treatment regimen including repeated intravenous infusions of allogeneic MSCs in dogs with refractory CIE. Methods Dogs with refractory CIE received repeated intravenous infusions of 2 × 10 6 cells/kg of allogeneic adipose-derived MSCs according to the following protocol: twice weekly at 3-4 day intervals for the first 2 weeks, once weekly for the next 2 weeks, and once every 2 weeks during the subsequent 4 weeks. We measured the Clinical Inflammatory Bowel Disease Activity Index (CIBDAI), Canine Chronic Enteropathy Activity Index (CCECAI), serum albumin concentration, and prednisolone dosage in each dog 30 days before treatment, immediately before treatment, and at 2 weeks, 1 month, and 2 months after the start of treatment. The primary endpoint of the treatment response was clinical remission ba

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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