Level D· Scientific groundwork from lab and animal studiesNarrative ReviewPubMed

[Prospects for stromal-vascular fraction in the treatment of lower limb ischemia].

Nekrasov DA., Puzanov AI.

Narrative Review on Chronic Inflammation, published in Khirurgiia (Mosk) (2025) — summary generated from the PubMed abstract.

Open my reading list
Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Narrative Review
Journal
Khirurgiia (Mosk) (2025)
Country
Russia (Federation)
Reported sample size
—
Source database
PubMed
PMID
41447217
DOI
10.17116/hirurgia202511274

Abstract (original English)

Stromal vascular fraction is a heterogeneous cell population with significant regenerative potential harvested from adipose tissue. Its cells stimulate angiogenesis, have anti-apoptotic and anti-inflammatory effects, stimulate cell growth and differentiation. This review highlights the mechanisms of action, as well as possibilities and results of local application of stromal vascular fraction in lower limb ischemia. Prospects of stromal vascular fraction for the treatment of lower limb ischemia are presented. Стромально-васкулярная фракция представляет собой гетерогенную клеточную популяцию, выделяемую из жировой ткани и обладающую существенным регенеративным потенциалом. Клетки, входящие в ее состав, стимулируют ангиогенез, оказывают антиапоптическое, противовоспалительное действие, стимулируют рост и дифференцировку клеток. Представленный обзор освещает механизмы действия, а также возможности и результаты локального применения стромально-васкулярной фракции при ишемии нижних конечностей. Показаны перспективы ее использования при терапии пациентов с ишемией нижних конечностей с отсутствием возможности или отказом от реваскуляризации.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

How we grade evidence
HumansIschemiaLower ExtremityStromal Vascular FractionNeovascularization, PhysiologicAdipose Tissue

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.

Related research