Protective/restorative Role of the Adipose Tissue-derived Mesenchymal Stem Cells on the Radioiodine-induced Salivary Gland Damage in Rats.
Saylam G., Bayır Ö., Gültekin SS., Pınarlı FA., Han Ü., Korkmaz MH.
Laboratory Study, published in Radiol Oncol (2017) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Radiol Oncol (2017)
- Country
- Poland
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 28959167
- PMCID
- PMC5611995
- DOI
- 10.1515/raon-2017-0022
- Citations
- 11
Abstract (original English)
To analyze protective/regenerative effects of adipose tissue-derived mesenchymal stem cells (ADMSC) on 131 I-Radioiodine (RAI)-induced salivary gland damage in rats. Study population consisted of controls (n:6) and study groups (n:54): RAI (Group 1), ADMSC (Group 2), amifostine (Group 3), RAI+amifostine (Group 4), concomitant RAI+ADMSC (Group 5) and RAI+ADMSC after 48 h (Group 6). We used light microscopy (LM), transmission electron microscopy (TEM), and salivary gland scintigraphy (SGS), and analyzed data statistically. We observed the homing of ADMSC in salivary glands at 1 st month on LM. RAI exposure affected necrosis, periductal fibrosis, periductal sclerosis, vascular sclerosis and the total sum score were in a statistically significant manner ( P < 0.05). Intragroup comparisons with LM at 1 st and 6 th months revealed statistically significant improvements in Group 6 ( P < 0.05) but not in Groups 4 and 5. Intergroup comparisons of the total score showed that Groups 4 and 5 in 1 st month and Group 6 in 6 th month had the lowest values. TEM showed vacuolization, edema, and fibrosis at 1 st month, and an improvement in damage in 6 th month in Groups 5 and 6. SGSs revealed significant differences for the maximum secretion ratio (Smax) ( P = 0.01) and the gland-to-background ratio at a maximum count (G/BGmax) ( P = 0. 01) at 1 st month, for G/BGmax ( P = 0.01), Smax ( P = 0.0
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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