Proteomic profile data of rabbit stem cell secretome and stem cell/tenocyte secretome and gene expression data, scratch assay data and CAM assay data of tenocyte in vitro cultures treated with these two different secreto

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Tendon rupture repairs exhibit two main problems. On the one hand side, they often lead to scar formation during healing, which has inferior mechanical properties and may lead to re-ruptures. On the other hand side, fibrotic adhesion formation to the surrounding tissue may occur, which hampers proper range of motion. Cell-free approaches to support tendon healing are getting increasing attention worldwide. We have therefore obtained two different cell secretomes from New Zealand White rabbit adipose tissue-derived mesenchymal stem cells (ADSCs) or from a 3:1 mixed culture of ADSCs and rabbit Achilles tenocytes. These cell secretomes were examined and compared in terms of their proteomic profiles and biological activities. Applied to a tenocyte in vitro culture, gene expression analysis data and scratch assay data are provided. To determine the angiogenic potential, the chorioallantoic membrane of the chicken embryo (CAM) was treated with the secretomes.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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