Protocol for the REBOUND study: a cohort study to uncover fundamental mechanisms of accelerated ageing and impaired resilience following cancer surgery and treatment
Welch C., Acharjee A., Birch R., de Magalhães JP., Duggal NA., Hainsworth A.
Cohort Study with a reported sample of 172, published in BMC Geriatr (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Cohort Study
- Journal
- BMC Geriatr (2025)
- Reported sample size
- 172
- Source database
- Europe PMC
- PMID
- 40629294
- PMCID
- PMC12235963
- DOI
- 10.1186/s12877-025-06109-y
- Citations
- 1
Abstract (original English)
Background Ageing is a heterogeneous process, which is associated with heterogeneous resilience in older people. Cancer surgery and treatment may be associated with accelerated ageing in some older people; studying this process will improve understanding to enable treatments to prevent adverse effects on physical and cognitive function. Methods This study will recruit 172 participants aged 65 years and older scheduled to undergo elective colorectal surgery for cancer from two hospital sites (Guy's and St Thomas' NHS Foundation Trust and University Hospitals Birmingham NHS Foundation Trust). Assessments will be performed preoperatively, days 1-3 postoperatively, 30 days postoperatively, and 90 days postoperatively. These will include in-depth clinical phenotyping including handgrip strength, Short Physical Performance Battery, muscle ultrasound, cognitive tests, Electroencephalography, questionnaires including quality of life, and physical activity using remote devices. Serial blood and stool specimens will be collected across timepoints to measure underlying hallmarks of ageing including inflammation, dysbiosis, macroautophagy, cellular senescence, epigenetic alterations, mitochondrial dysfunction, and stem cell exhaustion. A machine learning approach will be utilised to evaluate the associations between trajectories in clinical and physiological parameters and fundamental biol
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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