PRP or not PRP: Is the debate surrounding platelets-based blood-derived products evolving?
Ragni E., Taiana MM., Čengić T., de Girolamo L., Ostojić M.
Narrative Review, published in Knee Surg Sports Traumatol Arthrosc (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Knee Surg Sports Traumatol Arthrosc (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40079361
- PMCID
- PMC12022825
- DOI
- 10.1002/ksa.12655
- Citations
- 3
Abstract (original English)
The increasing interest in biologic treatments for musculoskeletal disorders has led to the advancement of orthobiologics, particularly in non-operative care through injectable therapies. However, defining these treatments clearly is crucial for proper clinical application. Orthobiologics include biologic substances that enhance healing, such as cell-based therapies and blood-derived products. Among these, platelet-rich plasma (PRP) is widely used, but its classification remains complex due to variations in preparation methods, platelet concentration, leucocyte content, and activation techniques. Strictly, the term 'PRP' refers to plasma enriched in platelets relative to baseline blood levels. Yet, scientific debate persists regarding whether platelet count or enrichment is more significant in clinical outcomes. Additionally, leucocyte-rich and leucocyte-poor PRPs offer different therapeutic advantages depending on the target tissue, complicating standardization. Similarly, the presence of red blood cells is generally discouraged, given their association with joint inflammation. Beyond the classical 'PRP' formulations, alternative blood-derived products offer distinct biological effects. A standardized classification system is therefore essential for research and clinical application, emphasizing precise documentation of products' characteristics, including platelet count, acti
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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