A Randomized Double-blind, Placebo-controlled Trial of Adipose-derived Regenerative Cells Injected into Corpora Cavernosum Following Radical Prostatectomy.
Hansen ST., Andersen DC., Jensen CH., Damkier P., Sørensen JA., Lund L.
Randomized Controlled Trial with a reported sample of 35, published in Eur Urol Focus (2026) — summary generated from the PubMed abstract.
Several human studies show positive signals, while research methods and sample sizes continue to develop.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Randomized Controlled Trial
- Journal
- Eur Urol Focus (2026)
- Country
- Netherlands
- Reported sample size
- 35
- Source database
- PubMed
- PMID
- 41760422
- DOI
- 10.1016/j.euf.2026.02.002
Abstract (original English)
Background and objective Erectile dysfunction (ED) following radical prostatectomy (RP) has a negative impact on quality of life. Herein, the aim was to assess the effectiveness of autologous adipose-derived regenerative cells (ADRCs) for treating ED after RP. Methods This was a randomized, double-blinded, placebo-controlled study. A total of 70 men with ED were enrolled at Odense University Hospital, Denmark. Patients received one intracavernous bolus of ADRCs (n = 35) or placebo (n = 35). The primary endpoint was a change in the International Index of Erectile Function 5 (IIEF-5) at 12 mo after intervention versus baseline. The secondary endpoints were changes in Erectile Hardness Scale (EHS) and RigiScan values at 6 mo versus baseline. Key findings and limitations There was no significant difference between the two groups in IIEF-5 (p > 0.99) and EHS (p = 0.85) scores. RigiScan values showed no overall effect of ADRCs versus placebo (tumescence activity units at the tip of the penis p = 0.19 and the base of the penis p = 0.60, and rigidity activity units at the tip of the penis p = 0.97 and the base of the penis p = 1). No severe adverse events were observed, and none had prostate-specific antigen relapse. Study limitations include the use of online surveys for patient registration of IIEF-5 and EHS scores. Conclusions and clinical implications Intracavernous injections of A
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Several human studies show positive signals, while research methods and sample sizes continue to develop.
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