Rat epididymal fat tissue express all components of the renin-angiotensin system.
Pinterova L., Krizanova O., Zorad S.
Animal Study, published in Gen Physiol Biophys (2000) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Gen Physiol Biophys (2000)
- Country
- Slovakia
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 11316063
- Citations
- 22
Abstract (original English)
In the present study the gene expression of components of the renin-angiotensin system was investigated in fat tissue of rats. mRNAs for angiotensinogen, renin, angiotensin-converting enzyme and type I (AT1) angiotensin II receptor were detected in the stromal-vascular fraction of the fat tissue and the same mRNAs, with the exception of the angiotesin-converting enzyme, in the adipocyte fraction. Renin and angiotensin-converting enzyme activity was measured. The main source of renin activity was found in adipocytes and some minor activity in the stromal-vascular fraction, while the majority of the angiotensin-converting enzyme activity was in the stromal-vascular fraction. The present data provide evidence for the presence of the active renin-angiotensin system in rat adipose tissue.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.