Recent advances in electroactive biomaterials and electrical stimulation for skeletal muscle regeneration: materials, strategies, and mechanistic insights
Jin M., Zhang Y., Lin W., Li Z., Liang W., An Y.
Narrative Review, published in Mater Today Bio (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Mater Today Bio (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 42011488
- PMCID
- PMC13092068
- DOI
- 10.1016/j.mtbio.2026.103053
- Citations
- 1
Abstract (original English)
Skeletal muscle tissue plays a crucial role in strength generation, body movement, posture maintenance, and the protection of internal organs. Volumetric muscle loss not only causes significant physical and psychological distress and disability for patients, but also poses a serious societal challenge due to the substantial financial burden it places on healthcare systems. Currently, available treatment methods for muscle tissue injury have inherent limitations. Tissue engineering has emerged as a promising therapeutic strategy to address this issue. Bioelectric activity has been widely recognized for their important role in maintaining skeletal muscle homeostasis and promoting regeneration. Electroactive biomaterial-enabled electrical stimulation (ES) has been shown to effectively regulate various biological processes and is expected to serve as an external intervention to accelerate skeletal muscle repair. In this review, we summarize the forms of electroactive biomaterials utilized in skeletal muscle tissue regeneration in recent years, and compare the performance advantages and limitations of various materials. Furthermore, ES strategies based on these electroactive materials and their specific applications in promoting skeletal muscle regeneration are systematically reviewed, including endogenous ES, exogenous ES, piezoelectric stimulation, magnetoelectric stimulation, and
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
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