Recent advances in metal-organic frameworks for therapeutic applications in periodontitis

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Periodontitis is a highly prevalent chronic inflammatory disease that leads to the destruction of periodontal tissues and has systemic health implications. Current treatments, such as mechanical debridement and antibiotics, are often inadequate due to poor biofilm penetration, drug resistance, and limited regenerative capacity. Metal-organic frameworks (MOFs) have recently emerged as a transformative platform to address these limitations and surpass traditional nanomaterials (e.g., liposomes, dendrimers). Their tunable porosity, multifunctional composition, and responsive degradation enable antibacterial, anti-inflammatory, and pro-regenerative actions. This review highlights the mechanisms by which MOFs combat periodontal pathogens, resolve inflammation, and promote tissue regeneration, outperforming conventional materials. We also discuss combinatorial strategies, such as photodynamic and immunomodulatory therapies, that enhance treatment efficacy. Despite promising preclinical results, challenges in biocompatibility, biodegradation, and clinical translation remain. Future efforts should focus on developing intelligent, multifunctional MOF platforms capable of microenvironment-responsive therapy to achieve complete periodontal restoration.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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