Red blood cell distribution width to albumin ratio is associated with osteoarthritis prevalence among US adults with diabetes using data from NHANES 2005 to 2018

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The aim of this study was to assess the relationship between red cell distribution width and albumin ratio (RAR) inflammatory markers and prevalence of osteoarthritis in a diabetic population by analyzing data from the National Health and Nutrition Examination Survey (NHANES). Using data from 2005 to 2018, using multivariate logistic regression, generalized additive models, and smooth curve fitting, we investigated the connection between RAR and osteoarthritis in diabetic individuals. Robustness checks included subgroup analyses. A total of 2698 participants were included in this study, in which the prevalence of osteoarthritis was 24.20%. After controlling for variables, multivariate logistic regression analysis revealed a significant and positive correlation between RAR levels and the prevalence of osteoarthritis (OR = 1.52, 95% CI: 1.24, 1.88). Smoothing curve analysis showed a significant nonlinear relationship between RAR levels and the prevalence of osteoarthritis (log likelihood ratio test P 0.05 for all interactions). Elevated RAR is associated with an increased prevalence of osteoarthritis in diabetic patients. This study supports the hypothesis of an association between RAR and osteoarthritis in the U.S. diabetic population, and diabetic individuals with elevated RAR levels should be particularly aware of their increased risk of developing osteoarthritis.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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