Regenerative potential of Dental Pulp Stem Cells (DPSCs) in dental and periodontal tissue engineering: a systematic review of preclinical and clinical studies

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Dental pulp stem cells (DPSCs) are multipotent mesenchymal stem cells with demonstrated potential for regenerating dental and periodontal tissues. This systematic review aimed to critically evaluate the regenerative potential, biological properties, and translational prospects of DPSCs in dental and periodontal tissue engineering, based on in vitro, in vivo, and clinical interventional studies published between 2010 and 2025. A comprehensive literature search was conducted in PubMed, Web of Science, Embase, and Scopus using combinations of keywords related to DPSCs, dental/periodontal regeneration, and tissue engineering. Quality assessment was performed using the Downs and Black checklist, and the risk of bias was also evaluated with RoB 2 and ROBINS-I tools. A total of 12 interventional studies (9 experimental and 3 clinical trials) were included. DPSCs consistently indicated high proliferation, multilineage differentiation, immunomodulatory capacity, and resistance to inflammatory and senescence-inducing conditions compared to other mesenchymal stem cell sources. Preclinical studies demonstrated the enhanced regeneration of dental pulp, dentin, periodontal ligament, cementum, and alveolar bone using DPSCs, with or without scaffolds and bioactive cues. Clinical trials reported the safety of autologous DPSCs and improvements in pulp vitality, probing depth, clinical attachment

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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