Regulatory roles of non-coding and exosomal RNAs in colorectal cancer: spotlight on angiogenesis
Moeinfar MS., Morshedi M., Keyhani A., Moosavi SSA., Kaikavoosnejad F., Rafiyan M.
Narrative Review, published in Clin Exp Med (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Clin Exp Med (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41331186
- PMCID
- PMC12769645
- DOI
- 10.1007/s10238-025-01979-3
- Citations
- 3
Abstract (original English)
Colorectal cancer (CRC) is a primary contributor to cancer-related mortality, largely due to its high metastatic potential. Although traditional treatments like surgery and chemotherapy have advanced, therapeutic resistance and relapse remain major challenges. Recent research has revealed that non-coding RNAs (ncRNAs) play pivotal roles in CRC progression, particularly by driving angiogenesis. Several classes of ncRNAs, including lncRNAs, miRNAs, and circRNAs, are key regulators of angiogenesis in CRC. For example, miRNAs such as miR-148a and miR-181a influence the VEGF and HIF-1α signaling pathways, which are critical for endothelial cell proliferation and migration. Certain lncRNAs, such as HNF1A-AS1 and UCA1, interact with miRNAs to modulate these pathways. CircRNAs (e.g., circ_0001821 and circ-ERBIN) often function as "miRNA sponges," sequestering angiogenesis-inhibiting miRNAs to promote tumor vascularization. Furthermore, exosomes act as intercellular communication vesicles that transport ncRNAs (miRNAs, circRNAs) within the tumor microenvironment (TME). This process enables cancer cells to remodel their environment and facilitate metastatic dissemination. Specifically, exosomal ncRNAs, such as circ_0000467 and circ_0081069, can regulate angiogenesis-related pathways. This review integrates current findings on the complex interactions between miRNAs, lncRNAs, circRNAs, an
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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