Repeatability in measuring curvature in Peyronie's disease
Wiborg MH., Krøijer R., Kallestrup EB., Laursen BS., Berg-Beckhoff G., Lund L.
Clinical Trial, published in Sex Med (2025) — summary generated from the PubMed abstract.
Several human studies show positive signals, while research methods and sample sizes continue to develop.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Clinical Trial
- Journal
- Sex Med (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41450750
- PMCID
- PMC12728819
- DOI
- 10.1093/sexmed/qfaf105
Abstract (original English)
Background Despite guideline recommendations to assess Peyronie's disease (PD) curvature during an intracavernous injection-induced erection, no standardized measurement protocol exists, and considerable interobserver variability remains. Aim To evaluate the interobserver reliability of penile curvature measurements in patients with PD and to determine if image annotation enhances measurement consistency. Methods In this study, 4 experienced urologists independently assessed erect penile curvature in 22 male patients enrolled in a prospective PD clinical trial. Two image sets per patient were analyzed: 1 consisting of self-captured photographs taken at home and the other obtained in the clinic after intracavernosal injection of alprostadil. Each image set included standardized lateral and dorsal views. The potential impact of an assisting line on photographic measurements was also evaluated. Outcomes Interobserver agreement in curvature measurement, the effect of line annotation on measurement accuracy, and the comparison of measurement consistency between home-acquired and clinic-induced erection images. Results Interobserver agreement was high, with Intraclass Correlation Coefficient values ranging from 0.77 to 0.88 across assessments. No statistically significant improvement in repeatability was observed with the addition of assisting lines. Furthermore, no meaningful differ
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Several human studies show positive signals, while research methods and sample sizes continue to develop.
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