[Research progress of adipose-derived stem cells in promoting the repair of peripheral nerve injury].

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

To summarize the research progress of adipose-derived stem cells (ADSCs) in promoting the repair of peripheral nerve injury. The related literature at home and abroad in recent years was widely reviewed, the mechanism of ADSCs promoting the repair of peripheral nerve injury was introduced, and its basic research progress was analyzed and summarized. Finally, the clinical transformation application of ADSCs in the treatment of peripheral nerve injury was introduced, the existing problems were pointed out, and the new treatment regimen was prospected. ADSCs have the function of differentiation and paracrine, and their secreted neurotrophic factors, antiapoptosis, and antioxidant factors can promote the repair of peripheral nerve injury. ADSCs are rich in content and easy to obtain, which has a definite effectiveness on the repair of peripheral nerve injury with potential clinical prospect. 总结脂肪来源干细胞（adipose-derived stem cells，ADSCs）在促进周围神经损伤修复方面的研究进展。. 广泛查阅国内外近年相关文献，分析 ADSCs 促进周围神经损伤修复的机制并总结基础研究进展；回顾 ADSCs 治疗周围神经损伤的临床转化应用，指出其目前存在的问题，并对新的治疗方案提出展望。. ADSCs 具有分化及旁分泌功能，其分泌的神经营养因子、抗凋亡、抗氧化等因子均能促进周围神经损伤修复。. ADSCs 含量丰富、易获取，对周围神经损伤修复具有较肯定的疗效，有较好的临床应用前景。.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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