Research progress and application prospect of engineered small extracellular vesicles
Zhang H., Chen J., Tang X., Liu X., Li Z.
Narrative Review, published in Cell Transplant (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Cell Transplant (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41562261
- PMCID
- PMC12827922
- DOI
- 10.1177/09636897251409473
Abstract (original English)
Extracellular vesicles (Evs) act as a natural intercellular message transmitter, Evs can carry proteins, ribonucleic acid (RNA) and other bioactive substances, and have rich biological regulatory functions. Because of its low immunogenicity and high biocompatibility, it has become a popular research object in drug delivery. These remarkable properties also create new opportunities for modern therapy. However, due to the complex preparation process, there are challenges in terms of targeting accuracy, load release controllability, and pharmacokinetic optimization, and many problems may be encountered in reality. Based on real-life biomedical experiments, this paper summarizes the methods and types of Evs loading drugs, membrane modification methods, and the use of biological materials to improve the release efficiency, so as to provide reference for future research on engineered Evs.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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