SVF
Level D· Scientific groundwork from lab and animal studiesNarrative ReviewPubMed

[Research progress of cells and cell-transplantation methods for periodontal tissue engineering].

Li W., Meng X.

Narrative Review on Ligament Injury, published in Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2010) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Narrative Review
Journal
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2010)
Country
China
Reported sample size
—
Source database
PubMed
PMID
21046816
Citations
1

Abstract (original English)

Objective To introduce the cells and cell-transplantation methods for periodontal tissue engineering. Methods Recent literature about application of cell-based therapy in periodontal tissue engineering was extensively reviewed, the cells and cell-transplantation methods were investigated. Results Mesenchymal stem cells were important cell resources for periodontal tissue engineering, among which periodontal ligament stem cells were preferred. Bone marrow mesenchymal stem cells had several disadvantages in clinical application, and adipose-derived stem cells might be a promising alternative; different transplantation methods could all promote periodontal regeneration to some extent. Single-cell suspension injection could only promote a little gingival regeneration, and tissue engineered scaffolds still needed some improvement to be used in periodontal regeneration, while cell sheet technique, with great cell loading ability and no need of scaffolds, could promote regeneration of cementum, periodontal ligament, and alveolar bone under different conditions. Conclusion Multipotent stem cells are fit to be used in periodontal tissue engineering; improvement of cell-transplantation methods will further promote periodontal regeneration.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

How we grade evidence
Cell DifferentiationPeriodontal LigamentRegenerationStem Cell TransplantationStem CellsTissue EngineeringTissue Scaffolds
Ligament Injury
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