[Research progress on effects of high glucose microenvironment on biological activity of adipose-derived stem cells].

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

To summarize the research progress of the effects of high glucose microenvironment on the biological activity of adipose-derived stem cells (ADSCs). The literature on the high glucose microenvironment and ADSCs at home and abroad in recent years was reviewed, and the effects of high glucose microenvironment on the general characteristics, differentiation potential, angiogenesis, and nerve regeneration of ADSCs were summarized. The accumulation of advanced glycosylation end products (AGEs) in the high glucose microenvironment led to changes in the biological activities of ADSCs through various pathways, including cell surface markers, proliferation, migration, multi-lineage differentiation, secretory function, and tissue repair ability. The ability of ADSCs to promote angiogenesis and nerve regeneration in high glucose microenvironment is still controversial. High glucose microenvironment can affect the biological activity of ADSCs, and the effect and mechanism of ADSCs on angiogenesis and nerve regeneration in high glucose microenvironment need to be further studied. 总结高糖微环境对脂肪来源干细胞（adipose-derived stem cells，ADSCs）生物学活性影响的研究进展。. 查阅近年国内外有关高糖微环境与 ADSCs 的文献，对高糖微环境对 ADSCs 的一般特性、分化潜能、促血管再生及促神经再生能力的影响进行总结。. 高糖微环境中，晚期糖基化终末产物积累后会通过多种途径导致 ADSCs 的生物学活性改变，包括细胞表面标记物、增殖、迁移、多谱系分化、分泌功能及组织修复能力等方面。目前对高糖微环境中的 ADSCs 促血管及神经再生能力尚存在争议。. 高糖微环境会影响 ADSCs 生物学活性，该微环境中 ADSCs 促血管及神经再生的作用及机制有待进一步研究。.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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