Research Progress on Spinal Cord Repair Based on Regulation of the Neuroregenerative Microenvironment

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Spinal cord injury is a disease with no complete cure. It typically results in loss of motor and sensory functions below the level of the lesion, leading to significant physical and psychological disorders. After spinal cord injury, the microenvironmental balance at the site of injury is disrupted, creating complex conditions that are not conducive to nerve regeneration and recovery of spinal cord function, such as hemorrhage and ischemia, glial scar formation, and nerve demyelination. As our knowledge of the spinal cord microenvironment has expanded, researchers have determined that therapeutic strategies that modulate the microenvironment represent a significant and efficacious avenue of investigation. This review summarizes the characteristics of microenvironmental changes at various stages after spinal cord injury. Additionally, it discusses novel strategies developed recently based on regulating the microenvironment after spinal cord injury to promote recovery. The investigation of a long-acting, targeted, and multitemporal combination therapy strategy to repair spinal cord injuries shows promise in terms of its developmental potential.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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