Research progress in the treatment of non-scarring alopecia: mechanism and treatment

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Introduction Non-scarring alopecia, encompassing androgenetic alopecia (AGA), alopecia areata (AA), and telogen effluvium (TE), is a common skin condition that significantly impacts both the physical and psychological wellbeing of affected individuals. This review aims to delve into the multifactorial etiology of non-scarring alopecia and to critically assess the current and emerging treatment options available for management. Methods The review methodology involved a comprehensive literature search in PubMed and Web of Science, focusing on the genetic, environmental, and psychological factors that contribute to the development of non-scarring alopecia. The search included studies published from 2004 to 2024, primarily in English, to incorporate both foundational and recent advancements in the field. The inclusion criteria encompassed clinical trials, meta-analyses, and high-quality observational studies investigating the pathogenesis and treatment of non-scarring alopecia. Case reports, editorials, and studies with insufficient methodological details were excluded. Additionally, this review evaluated FDA-approved treatments (e.g., minoxidil and finasteride) and emerging therapeutic agents, such as Janus kinase (JAK) inhibitors and natural remedies, with an emphasis on their mechanisms, efficacy, and safety profiles. Results The findings from this review indicate that the curre

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.