A review on β-cyclodextrin-based self-healable supramolecular systems: mechanisms and biomedical applications
Sultana N., Bhowmik S., Bilkis K., Hossen Akash M., Afrose F., Fatema K.
Narrative Review, published in RSC Adv (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- RSC Adv (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41924099
- PMCID
- PMC13036499
- DOI
- 10.1039/d6ra00694a
Abstract (original English)
Supramolecular self-healing materials have attracted significant interest due to their capacity for autonomous damage repair, which enhances their durability and functional performance. This review examines the design strategies and recent advances in self-healing systems driven by host-guest interactions, with a particular focus on cyclodextrin (CD)-based architectures. β-Cyclodextrin (β-CD), owing to its biocompatibility and strong ability to form inclusion complexes, serves as a crucial building block in the design of host-guest-based self-healing systems. These self-healable materials have garnered significant attention owing to their potential applications in various fields, specifically biomedical applications. This review highlights the recent advancements in β-CD-based supramolecular materials, focusing on their unique host-guest (HG) interactions that result in the emergence of their self-healing properties. We discuss β-CD and its ability to form inclusion complexes with a range of guest molecules, which promotes reversible interactions that are critical for self-healing mechanisms. The synthesis methods, structural design, and influence of environmental conditions on the healing efficiency of these materials are critically analyzed. Furthermore, we explore the performance of β-CD-based systems in practical applications and provide insights into future research direct
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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