RF15 | PMON305 Membrane Progesterone Receptor α (mPRα/PAQR7) Promotes Survival and Axonal Sprouting in Human Neuronal Cells Lines Through Direct and Human Schwann-Cell Like Differentiated Adipose Stem Cells-Mediated Mech
Prospective Study, published in J Endocr Soc (2022) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- J Endocr Soc (2022)
- Reported sample size
- —
- Source database
- Europe PMC
- PMCID
- PMC9627772
Abstract (original English)
Abstract Injuries to peripheral nerves affect millions of people worldwide. These injuries can be significantly detrimental to the patients’ quality of life. While central nervous system neurons have extremely limited regenerative potential, peripheral nerves are able to regenerate after injury. However, this regeneration process often leads to unsatisfactory regenerative outcomes. Improving peripheral nerve regeneration is therefore a strong medical need. Schwann cells, the glial myelinating cells of the peripheral nervous system, are known to play an important role in promoting peripheral nerve regeneration. However, their limited in vitro expansion capability and limited availability has led several research groups to investigate the possibility of using differentiated stem cells as a potential tool to promote nerve regeneration, in association with other tools such biomaterial tubes. The activation of membrane progesterone receptor α (mPRα, PAQR7) with the selective agonist 19-ethenyl-progesterone (02-0) was recently shown to elicit potentially pro-regenerative effects in a model of human Schwann cell-like (SCL) differentiated adipose stem cells (ASC). Indeed, mPRα activation led to increased SCL-ASC migration, proliferation and neurotrophin (specifically BDNF) release. All these outcomes are expected to be beneficial for nerve regeneration. In this project, we investigated
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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