The role of adipose-derived stem cells in endometrial cancer proliferation.
Linkov F., Kokai L., Edwards R., Sheikh MA., Freese KE., Marra KG.
Prospective Study, published in Scand J Clin Lab Invest Suppl (2014) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Scand J Clin Lab Invest Suppl (2014)
- Country
- Norway
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 25083894
- DOI
- 10.3109/00365513.2014.936682
- Citations
- 9
Abstract (original English)
Background Obesity has been identified as a key risk factor for the development of endometrial cancer (EC), the most common gynecologic malignancy in the US. We hypothesized that adipose tissue from EC patients secretes higher levels of cancer-promoting factors than healthy adipose tissue and promotes tumor cell growth. Methods In this study, we generated conditioned media from adipose-derived stem cells (ASCs), an important regenerative cell population within adipose tissue. ASCs were isolated from adipose tissue from two EC patients undergoing hysterectomies and four cancer free control patients undergoing elective abdominoplasties. Ishikawa cells were then cultured for 48 hours in ASC-conditioned media (ASC-CM). Study outcomes included cancer cell proliferation rates and angiogenic factor secretion from cancer cells. Results Our results indicate that ASC-conditioned media significantly increased Ishikawa cell proliferation rate when compared to control Ishikawa culture conditions (p = 0.002). Though not significant, Ishikawa proliferation with conditioned media from EC ASCs was higher than proliferation in conditioned media from control ASCs. Additionally, we found that Ishikawa cells secreted almost 10 % more vascular endothelial growth factor (VEGF) when cultured in EC ASC-CM as compared to Ishikawa cells cultured in healthy (cancer free control) ASC-CM. These results indi
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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