The Role of Adipose Tissue-Derived Stem Cells together with Vitamin C on Survival of Rats with Acute Radiation Syndrome.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Following any injury in radiation accidents, such as Acute Radiation Syndrome (ARS), medical interventions are recommended based on radiation dose and physiological response. Clinical management encompasses blood transfusion, hematopoietic cytokines, and stem-cell transplantation. Objective This study aimed to determine the effect of adipose tissue-derived stem cells (AdSCs) together with vitamin C on the survival of rats with ARS. Material and methods In this experimental study, 45 rats were randomly divided into 3 equal groups of animals administered with a single dose of oral 400 mg/kg vitamin C; those injected intravenously with 1.5×10 5 AdSCs; and rats transplanted intravenously with 1.5×10 5 AdSCs together with a single oral dose of 400 mg/kg vitamin C. All rats were already irradiated with 10 Gy (dose rate 0.286 Gy/ min) 60 CO, for 35 minutes with a field size of 35 cm × 35 cm for all body areas. Results A significant increase in survival rate was visible one month after γ irradiation in 73.3% of animals received AdSCs+vitamin C, 60% of rats injected with just AdSCs, and 13.3% of the group received just vitamin C. Conclusion Our findings revealed significant efficacy of a combined approach involving AdSC transplantation and vitamin C to enhance the survival rate following lethal irradiation. This combination could offer a potential avenue for addressing the al

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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