Role of Adrenal Progenitor Cells in the Structural Response of Adrenal Gland to Various forms of Acute Stress and Subsequent Recovery in Adult Male Albino Rats

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Stress is a response to stressogenic stimuli that interferes with an organism's homeostasis. The adrenal gland is crucial in the body's reaction to stress. Objective This study compared the effects of immobility and cold as acute stressors and the subsequent recovery on the histological changes of the adrenal gland and the suspected role of the adrenal progenitor cells. Materials and methods Thirty-five adult male albino rats were divided equally into five groups. Group I: Control group, Group II: Rats subjected to the acute cold stress procedure, Group III: Rats subjected to the acute immobilization stress procedure, Group IV: The combined stress group, and Group V: Similar to the combined stress group and recovered for 6 days then sacrificed 1 day later. Serum cortisol level was determined, and the adrenal glands were processed for histological and immunohistochemical studies. Results Serum cortisol concentration was higher in the acute-stress groups and decreased in the recovery group. The adrenal cortex had enlarged, vacuolated cells with pyknotic nuclei, sinusoidal dilatation, and congestion. Chromaffin cells were crowded, enlarged, and vacuolated. There was strong immunohistochemical reactivity for heat shock protein-70 and caspase-3. In addition, the combined group showed a significant increase in the optical density of chromogranin-A in the medullary cells as

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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