Role of long non-coding RNAs in cartilage development and osteoarthritis pathogenesis

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Osteoarthritis (OA) is a progressive joint disease characterized by the degradation of cartilage, remodeling of subchondral bone, and inflammation of synovial tissue, posing growing global health challenges. Long non-coding RNAs (lncRNAs) play crucial roles in various physiological and pathological processes associated with OA, including extracellular matrix (ECM) degradation, synovial inflammation, chondrocyte apoptosis, and angiogenesis. Chondrogenesis involves mesenchymal cell condensation followed by differentiation into chondrocytes, hypertrophy of chondrocytes, and subsequent maturation. This review aims to provide an updated overview of lncRNAs and their involvement in cartilage development as well as OA. Furthermore, we discuss the potential utility of lncRNAs as molecular biomarkers for early diagnosis and treatment of OA.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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