The Role of Vascularization in Nerve Regeneration: Mechanistic and Therapeutic Perspectives
Malekzadeh H., Otto-Moudry R., Moore AM.
Narrative Review, published in Int J Mol Sci (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Int J Mol Sci (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40943315
- PMCID
- PMC12428457
- DOI
- 10.3390/ijms26178395
- Citations
- 2
Abstract (original English)
Peripheral nerve injuries (PNIs) are common and often result in sensorimotor deficits, chronic pain and decreased quality of life. While the peripheral nervous system has greater regenerative capacity than the central nervous system, recovery is often limited by intrinsic changes in the nerve and muscle. This review summarizes the process of nerve regeneration, with a focus on the role of the vasculature, following PNI and examines current bioengineering approaches to enhance peripheral nerve regeneration through modification of the nerve microenvironment and optimization of neurovascular interactions. The primary areas of translational research discussed in this review include vascularized nerve grafts, nerve conduits and scaffolds, bioactive peptides, nanoparticles, extracellular vesicles, stem cells, and gene therapy.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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