Roles of Exosome-Derived Noncoding RNA in Fibrosis
Wang Y., Le Z., Shi R., Li K.
Narrative Review, published in Mol Cells (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Mol Cells (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41475536
- PMCID
- PMC12861206
- DOI
- 10.1016/j.mocell.2025.100309
- Citations
- 1
Abstract (original English)
Fibrosis is a chronic, progressive disease characterized by the excessive accumulation of extracellular matrix (ECM) in tissues and organs during damage-repair responses. This pathological process can involve almost any tissue or organ and may eventually lead to organ failure, posing a major threat to human health. ECM production is closely related to intercellular communication. As one of the biologically active substances participating in intercellular communication, exosomes have attracted increasing attention in recent years. In particular, noncoding RNAs (ncRNAs) enriched in exosomes regulate gene expression at multiple levels and influence the fibrosis process. Common ncRNAs include miRNA, long ncRNAs, circRNA, and tRNA, which can be selectively loaded into exosomes by various cells to modulate receptor cell functions. In fibrosis-related diseases, the primary sources of exosome-derived ncRNAs (Exo-ncRNAs) include mesenchymal stem cells, macrophages, epithelial cells, and fibroblasts. These Exo-ncRNAs regulate macrophage polarization, epithelial-mesenchymal transition, and fibroblast-myofibroblast transdifferentiation within the microenvironment. In this review, we summarize the regulatory roles and molecular mechanisms of these ncRNAs in the fibrosis process, and discuss Exo-ncRNAs with potential therapeutic effects. Understanding Exo-ncRNAs from different cell sources m
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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