From scaffold to function: A systematic review on dLECM-based hydrogels for liver tissue engineering - Fabrication, properties, and translational applications
Majidi Z., Sarvi MM., Rajabi MA., Firouzian H., Seyhoun I., Majidi Zolbin M.
Systematic Review, published in Regen Ther (2026) — summary generated from the PubMed abstract.
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Systematic Review
- Journal
- Regen Ther (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41340925
- PMCID
- PMC12670586
- DOI
- 10.1016/j.reth.2025.11.006
- Citations
- 2
Abstract (original English)
Background Liver tissue engineering is a rapidly advancing field aiming to address the critical shortage of donor organs and improve in vitro models for drug screening and disease modeling. Decellularized liver extracellular matrix (dLECM)-based hydrogels have emerged as a leading biomaterial platform due to their ability to preserve the native biochemical composition, microstructure, and biomechanical cues of the liver microenvironment. This systematic review aims to comprehensively evaluate the methodologies, physicochemical properties, biological performance, and translational applications of dLECM-derived hydrogels in liver tissue engineering, with a focus on fabrication protocols, functional outcomes, and challenges toward clinical implementation. Methods A systematic search was conducted in accordance with PRISMA 2020 guidelines across PubMed, Scopus, Google scholar and Web of Science. A total of 74 studies were included after screening 536 records identified from databases. Data were extracted on tissue source, decellularization techniques, dECM solubilization, hydrogel formulation, crosslinking methods, physicochemical characterization, and in vitro / in vivo functional outcomes. Results The majority of studies utilized porcine or rodent livers, with immersion/agitation and vascular perfusion as the primary decellularization methods. Sodium dodecyl sulfate (SDS), Triton
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
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