Seahorse-assessed metabolic data, CAM assay data and aspect ratio data of tenocyte in vitro cultures treated with insulin-like growth factor-1 (IGF-1), with platelet-derived growth factor-BB (PDGF-BB) or with IGF-1 and P

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

As tendon rupture repair still implies problematic outcomes for the patients, such as re-rupture or adhesion formation to the surrounding tissue, restricting the capability for full loading or the range of motion, novel approaches are welcome and many research groups are working on the optimization of tendon repair. For example, growth factor delivery to the ruptured tendon may support the natural healing by accentuating growth factor dynamics that otherwise occur naturally. We have therefore tested insulin-like growth factor-1 (IGF-1) and platelet-derived growth factor-BB (PDGF-BB) or both mixed together under in vitro conditions, supplementing the growth factors to cell culture medium of rabbit Achilles tenocytes and rabbit adipose-derived stem cells. We have assessed the effects on the cell morphology and provide aspect ratio data, as well as metabolic data determined by Seahorse experiments, and finally CAM assay data referring to several angiogenic readouts, respectively.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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