Semitendinosus myopathy and treatment with adipose-derived stem cells in working German shepherd police dogs.
Gibson MA., Brown SG., Brown NO.
Animal Study with a reported sample of 8, published in Can Vet J (2017) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Can Vet J (2017)
- Country
- Canada
- Reported sample size
- 8
- Source database
- PubMed
- PMID
- 28246410
- PMCID
- PMC5302197
- Citations
- 16
Abstract (original English)
Semitendinosus myopathy has been treated with numerous surgical and non-surgical therapies resulting in recurrence of lameness within 2 to 9 months. Eleven cases of semitendinosus myopathy diagnosed in 8 working police dogs that were treated with adipose-derived mesenchymal stem cells were retrospectively evaluated. At short-term follow-up < 6 mo, ultrasound and gait evaluations revealed a mean reduction in the overall intramuscular lesion size of 54.82% (SD +/- 18.02; range: 30.5% to 82.7%) and reduction in the Visual Assessment Score (VAS) of 1 to 3 points. At long-term follow-up > 1 y, in 8 cases the dogs had a normal gait and in 3 cases the dogs had an improved gait compared with initial examination, and all 8 dogs returned to active police work. Fisher's exact test resulted in P = 0.000008 when comparing published historical reports and these 11 cases for resolution of lameness and return to active duty. Myopathie du muscle semi-tendineux et traitement à l’aide de cellules souches adipeuses chez des chiens policiers Bergers allemands. La myopathie du muscle semi-tendineux a été traitée à l’aide de nombreuses thérapies chirurgicales et non chirurgicales qui ont produit une récurrence de la boiterie dans un délai de 2 à 9 mois. Onze cas de myopathie du muscle semi-tendineux diagnostiqués chez 8 chiens policiers qui avaient été traités à l’aide de cellules souches mésenchymat
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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