Significance of Textile Properties for the Design of a New Pelvic Implant to Treat Pelvic Organ Prolapse

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Introduction and hypothesis Pelvic organ prolapse (POP) is a condition that affects millions of women worldwide with grave impact on their mental, social and sexual health. Previously, the polypropylene (PP) mesh was used to augment POP surgery. However, in 2019 the PP mesh was banned across multiple countries due to major complications and women were left with no alternative options. Complications arise, in part, secondary to the textile properties of the PP mesh. Development of a new pelvic implant to overcome previous complications will need to consider all these factors and optimise textile properties to enhance cell behaviour and tissue integration. Methods A critical literature review was conducted using PubMed/Medline, Embase, and the Cochrane Library (Wiley). Studies published in the last ten years analysing the textile properties of pelvic implants were included. Eligible papers investigated material composition, fibre type, pore size and porosity, and manufacturing techniques. Results PP meshes were associated with stiffness, deformation, and chronic inflammatory responses. Alternative materials such as polyurethane (PU), polyvinylidene fluoride (PVDF), polylactic acid (PLA) demonstrated enhanced elasticity, biocompatibility, and mechanical integrity. Electrospinning and wet spinning allowed finer control over fibre morphology and porosity. Optimal outcomes were obser

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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