Six Hundred and Sixty Nanometer Light Exposure-Induced Alterations in Actin Filament, Mitochondrial Morphological Dynamics, and Migration in Mesenchymal Stem Cells.
Rastogi M., Sahu K., Majumder SK.
Laboratory Study, published in J Biophotonics (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Biophotonics (2025)
- Country
- Germany
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40908809
- PMCID
- PMC12809618
- DOI
- 10.1002/jbio.202400544
- Citations
- 1
Abstract (original English)
Actin cytoskeleton alteration and cell homing/migration are crucial determinants for the success of stem cell (SC) based therapy. Photobiomodulation (PBM) is a promising non-pharmacological approach for modulating SC potency. Though ~660 nm is the most studied wavelength for the proliferation/differentiation of SCs, the migration and cytoskeleton remodeling aspects have not been investigated in detail. In this study, we report the effect of ~660 nm on actin filaments, mitochondrial morphological dynamics, along with the migration of human adipose-derived mesenchymal stem cells (hADMSCs). Exposure to ~660 nm (~15 J/cm 2 ) elicits rapid actin fiber rearrangement leading to elongated, parallel fibers, and mitochondrial granulation along the leading edge of cell migration. In addition, 660 nm (~15 J/cm 2 ) also enhances cell proliferation, ATP, and ROS levels. These ultrastructural and biochemical alterations, in conjunction with the increased cell migration, shed new light on mechanistic perspectives to elicit enhanced homing/migration in SCs and would help in further optimization of ~660 nm based SC priming.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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