Sprouting and network data assessed in the chicken aortic ring assay under stimulation with human adipose-derived stem cell secretomes harvested from single cells or spheroids of different sizes.
Wolint P., Hofmann S., von Atzigen J., Böni R., Miescher I., Giovanoli P.
Laboratory Study, published in Data Brief (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Data Brief (2025)
- Country
- Netherlands
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40027245
- PMCID
- PMC11870177
- DOI
- 10.1016/j.dib.2025.111371
- Citations
- 2
Abstract (original English)
The aortic ring assay is widely used to assess the angiogenic modulation evoked by various drugs. However, different parameters are used as readouts and there is no congruence in terminology. In addition, some researchers use one set of parameters, and other researchers choose parameters that overlap to some extent, but miss a part of these parameters, rendering a direct comparison of the readouts and results difficult [1]. Therefore, we present data acquired in the chicken aortic ring assay that cover the full spectrum of possible readouts - exemplified by stimulation with secretomes harvested from human adipose-derived stem cells, cultivated either as single cell monolayer culture or as 3D spheroids, sized 250 cells/spheroid or 8000 cells/spheroid, respectively.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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