Stem cell therapy for erectile dysfunction: promise or reality? - a systematic review and meta-analysis of clinical trials
Senel S., Sevinc AH., Gultekin H., Ravshanbekovich AJ., Besiroglu H., Dursun M.
Meta-analysis, published in BMC Urol (2025) — summary generated from the PubMed abstract.
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Meta-analysis
- Journal
- BMC Urol (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40883730
- PMCID
- PMC12395856
- DOI
- 10.1186/s12894-025-01913-5
Abstract (original English)
Background The outcomes of clinical trials on stem cell therapy (SCT) on erectile dysfunction (ED) treatment are promising but there is still no conclusive evidence regarding its efficacy. The aim of this meta-analysis is to compile studies that assess the effectiveness of SCT on ED to reach a more reliable conclusion. Methods The meta-analysis was registered to PROSPERO (CRD42024540511). We utilized the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline to report the outcomes. Articles published from January 2000 to May 2024 were included for systematic review. We performed a systematic search using keywords: "stem cell" AND ("erectile dysfunction" OR "erectile function" OR "erection" OR "impotence"). Results We initially identified 2,013 studies in full publications or abstracts using the search terms. Eleven studies were included in systematic review and six of them were included in meta-analysis. Most studies included in systematic review reported improvements in erectile function following intracavernosal SCT. The meta-analysis revealed significant improvements at six months in international index of erectile function-5 (IIEF-5), international index of erectile function-erectile function domain) IIEF-EF, erectile hardness score (EHS), and peak systolic velocity (PSV) (p 0.05). Conclusion Intracavernosal SCT may increase scores on the ques
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
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